The body’s ability to adapt to changing conditions and shifting physiologic demands is essential to survival. To do so, each cell must be able to dispose of damaged or unnecessary proteins—a quality-control mechanism critical for cellular performance and for the health of the entire organism.

Now, a study from Harvard Medical School shows that intense exercise, fasting and an array of hormones can activate cells’ built-in protein disposal system and enhance their ability to purge defective, toxic or unneeded proteins.